I can't agree more with the previous poster, however, if you are simply looking for a race/class setup to learn the basics and mechanics of the game, and you want one that is relatively easy to play at lower levels while you are getting the hang of things, I would have to go with a warforged fighter.
And here are my reasons why:
Warforged: You start off the game with many immunities which will help immensely while you are getting your bearings. You also can get 25% fortification, to help with some of those critical hits.
Fighter: The high HPs coupled with the ability to use almost every weapon/armor in the game makes this an excellent choice for someone just trying to get a feel for the game. You can start straight off with a relatively powerful character who you can solo with if you choose, or be a great asset to a party.
I am not by an means saying that this is the "best" race/class makeup, that is completely up to you and your playing style and what you want from the game. The beauty of DDO is that whatever race/class you choose you will have endless possibilities for ways to customize your character and make them unique.
Hope this helps a little.
Enjoy!!